WebSeQuant ® HILIC (hydrophilic interaction liquid chromatography) HPLC columns constitute a range of high-performance tools for separating polar hydrophilic compounds. All columns carry densely bonded, truly zwitterionic functional groups with a charge balance of 1:1. WebHILIC is generally recommended for compounds with negative log P values. Another important analyte parameter is the pK a (-log K a) value; K a gives us an indication of the acidity of a molecule. The larger the pK a value, the weaker the acid. log D provides a good indication of the ionization state of a compound in solution at a specific pH.
DART-MS Facilitated Quantification of Cannabinoids in Complex …
WebWith HILIC methods, the high concentration of organic solvent in the mobile phase raises the pH, and the actual eluent pH can be 1–1.5 units higher than in the aqueous portion alone. The charge state of the column itself can also be affected. WebHello HILIC… Protecting your laboratory productivity Recommended Reading Sample Prep Pointers - Peptide Mapping Part I Save your results with sample filtration Simplified cone inspection with the new Agilent LED measuring magnifier Software - Supported Method Development - The Scanview Application Software tool for the ADM Flow Meter (G6691A) databricks move cell
Hydrophilic Interaction Chromatography (HILIC) for Small …
WebMar 19, 2024 · The applications of HILIC across each field include: Pharmacology: To analyze drugs and their metabolites. Biochemistry: Metabolic pathways and biomarkers for disease. Food industry: Peptide mapping, vitamins, contaminants and toxins. Agriculture: Environmental toxins and polar analytes found in plant extracts. WebApr 14, 2024 · Though not included in Table 1 due to being proprietary software, Lipid Annotator , Lipostar , and MetaboScape (Bruker Daltonics, Billerica, MA, USA) are specialized tools that can process IMS-MS lipidomics data from Agilent, Waters, and Bruker platforms, respectively. MS-DIAL requires the files to be converted to an IBF format, whereas Skyline ... WebAgilent acquires Polymer Standards Service (PSS), broadening offerings for gel permeation chromatography (GPC) and size exclusion chromatography (SEC) polymer analysis. The … Agilent offers three unique, orthogonal HILIC phases: bare silica (HILIC), … marriott hotel amalfi coast