Cisplatin dna cross-linking

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WebJul 8, 2009 · The two opposing guanine residues involved in the cross-link were identified via limited alkaline hydrolysis. The kinetics of aquated cisplatin binding to the BBD RNA, a related RNA hairpin, and its DNA hairpin analogue were investigated in an ionic background of 0.1 M NaNO (3) and 1 mM Mg (NO (3)) (2). WebApr 17, 2024 · The antitumor effects of cisplatin and other platinum compounds are attributed to their ability to induce interstrand DNA-DNA cross-links, which are thought …

Interstrand Cross‐Links in Cisplatin‐ or …

WebThe platinum 1,3-d(GXG) intrastrand cross-link is one of the adducts formed in the reaction of the antitumor drug cisplatin with DNA, and in fact the major adduct found in cells treated with the cisplatin analogue carboplatin. ... cross-link and other Pt-DNA cross-links sheds new light on the observed differences in protein recognition of these ... WebCisplatin produces DNA cross-linking and is used to treat medulloblastoma, head and neck, ovarian, germ cell, cervical, lung and bladder cancers. Cisplatin produces a … high waisted cuff shorts etsy pattern

Molecules Free Full-Text The Challenging Treatment of Cisplatin ...

WebOct 28, 2003 · A dominating preference for initial attack at the N7-position of guanine is established experimentally, which is a crucial first step for the formation of a 1,2-intrastrand cross-link of adjacent guanine bases that leads to bending and unwinding of DNA. WebFeb 1, 2002 · To overcome this obstacle, researchers have focussed their attention on cisplatin (cis-DDP; cis-platinum (II)diamminedichloride), a cross-linking agent shown to … WebThe drug reacts with nucleophilic sites in DNA forming monoadducts as well as intra- and interstrand crosslinks. DNA-cisplatin adducts are specifically recognized by several … high waisted crotchless support hose spanx

Roles of DNA damage in renal tubular epithelial cells injury

Solution structure of a DNA duplex containing a cis …

WebJul 23, 1996 · Abstract cis-Diamminedichloroplatinum (II) (cisplatin) is a widely used anticancer drug that binds to and crosslinks DNA. The major DNA adduct of the drug results from coordination of two adjacent guanine bases to platinum to form the intrastrand crosslink cis- [Pt (NH3)2 [d (GpG)-N7 (1), -N7 (2)]] (cis-Pt-GG). WebJun 24, 2011 · For example, cisplatin, the most widely used crosslinking drug, causes damage that is estimated to comprise of 90% intrastrand crosslinks (predominantly crosslinks between adjacent purine... how many federal inmatesWebFeb 21, 2000 · Most simple cis-PtA2G2 complexes that model the G-G cross-link DNA lesions caused by the clinically used anticancer drug cis-PtCl2 (NH3)2 undergo large fluxional motions at a rapid rate (A2 = two amines or a diamine; G = guanine derivative). how many federal judges are black

"Webwww.ncbi.nlm.nih.gov " - Cisplatin dna cross-linking

Cisplatin dna cross-linking

Mechanism of the formation of DNA–protein cross-links …

WebTumour cells isolated from 50 ovarian cancer patients were treated ex vivo with 100 μ M cisplatin for 1 h and crosslink formation and repair (unhooking) measured. ... in cellular mechanisms such as drug transport or detoxification. In contrast, the percentage repair (unhooking) of DNA interstrand crosslinks was much greater in the group of ... WebDec 22, 2024 · Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes …

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WebCisplatin Medicine & Life Sciences 74%. DNA Repair Medicine & Life Sciences 50%. DNA Medicine & Life Sciences 46%. DNA Adducts Medicine & Life Sciences 34%. ... (II) and Modification of Platinum-induced DNA Interstrand Cross-Linking. / Swinnen, Lode J.; Barnes, Diane M.; Fisher, Susan G. et al. WebThis chapter deals with the interstrand cross-links in cisplatin- or transplatin-modified DNA and focuses on three main aspects: the formation of the interstrand cross-links, the distortions induced in the DNA double helix and the potential use of the interstrand cross-linking reaction in the context of antisense and antigene strategies.

WebSep 28, 2012 · DNA cross-linking agents such as the nitrogen mustards (melphalan, chlorambucil, cyclophosphamide, ifosfamide), platinum drugs (cisplatin, carboplatin, oxaliplatin), chloroethylnitrosoureas (carmustine, lomustine), the alkylalkane sulphonate busulphan and the natural product mitomycin C are widely used drugs as both single … WebCisplatin is one of the most widely used agents in cancer chemotherapy. Its mode of action is cross-linking of the DNA, which can kill cells. But which part of the genome is more …

WebPhoto-cross-linking is thus an effective tool for investigating the interaction of cisplatin-modified DNA with damage-recognition proteins under heterogeneous conditions such … WebCisplatin crosslinks DNA in several different ways, interfering with cell division by mitosis. The damaged DNA elicits DNA repair mechanisms, which in turn activate apoptosis when repair proves impossible.

WebThis chapter deals with the interstrand cross-links in cisplatin- or transplatin-modified DNA and focuses on three main aspects: the formation of the interstrand cross-links, the …

WebWe evaluated the growth and molecular interactions of the anti-EGFR antibody cetuximab (erbitux) and the DNA cross-linking agent cisplatin (cis-diammedichloroplatinum; CDDP) in the gefitinib-resistant MDA-MB-468 breast cancer cell line, an in vitro model system that shows many of the recurrent basal-like molecular abnormalities including … high waisted cuffed denim shortsWebfavors cisplatin cross-linking (20) with inter- and intra-DNA strands (14,17,26). Cisplatin interacts primarily with cytosine- and guanine-rich DNA regions (29) and causes cellular damage. Despite its potent antineoplastic action, cisplatin’s major side effects include nephrotoxicity (2), peripheral neuropathy (33), azoospermia (11). In mammals, high waisted cropped wide jeansWebOct 26, 1995 · Solution structure of a cisplatin-induced DNA interstrand cross-link. The widely used antitumor drug cis-diamminedichloroplatinum (II) (cisplatin or cis-DDP) … how many federal judges are thereWebAug 8, 2010 · Cisplatin-induced DNA damage activates various signaling pathways to prevent or promote cell death. This paper summarizes our current understandings … high waisted culotte pants millyWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … how many federal judges are there in texasWebAs we have seen from studies into the mode of action of cisplatin, covalent intrastrand cross-links can also be formed by chemical agents, such as cisplatin. A similar mechanism is believed to repair damage done to cancer cells by cisplatin, as we will see when we discuss drug resistance. how many federal judges did reagan appointWebDNA crosslinking agents, such as cisplatin derivatives (carboplatin and oxaliplatin) and mitomycin C, are especially cytotoxic to tumor cells, and their therapeutic index derives, … high waisted cuff denim shorts