Chimeric polynucleotide
WebSep 10, 2024 · In particular, the invention provides chimeric antigen receptors (CARs) comprising such CCR9 binding domains. WO2024037125A1 - Binding domain - Google Patents ... the cell, the polynucleotide, the vector and/or the pharmaceutical composition may be administered to a subject having an existing disease or condition in order to … WebA Chimeric Antigen Receptor (CARs) may be introduced into a T cell in vitro to direct the T cell, once re- introduced into the subject, to selectively kill tumor cells based on expression of an...
Chimeric polynucleotide
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WebThe double-stranded template polynucleotide can be from about 200 base pairs to about 20 megabase pairs in length and the single-stranded regions can be from about 5 bases to about 50,000 bases... WebJul 7, 2016 · We claim: 1. A chimeric polynucleotide encoding a polypeptide, said chimeric polynucleotide having a sequence comprising Formula I, 5′[A n] x-L1-[B o] y-L2-[C p] z-L3 3′ I wherein: each of A and B independently comprise a region of linked nucleosides; C is an optional region of linked nucleosides; at least one of regions A, B, or …
WebBR-0112566-A chemical patent summary. WebThe present invention relates to the field of plant molecular biology and plant genetic engineering, and polynucleic acid molecules useful for gene expression in plants. Specifically, the present invention discloses chimeric polynucleic acid molecules that function as promoters in plant cells.
WebU.S. Patent Application US20160108395A1 for chimeric single-stranded polynucleotides and double-stranded antisense agents useful for modifying the expression of a target gene by means of an antisense effect are disclosed. The chimeric single-stranded antisense polynucleotide and double-stranded antisense agents comprise a central nucleotide … WebThe polynucleotide sequence of the 2A peptide in the chimeric polynucleotide may be modified or codon optimized by the methods described herein and/or are known in the art. Notwithstanding the foregoing, the chimeric polynucleotides of the present invention may comprise a region or part which is not positionally modified or not chimeric as ...
WebJul 7, 2016 · The chimeric polynucleotide of any of the preceding claims wherein the polypeptide is selected from the group consisting of biologics, antibodies, vaccines, …
WebThe chimeric TNFα is therefore useful in methods for inducing apoptosis of a cell expressing a TNFα receptor, inducing activation of an immune system cell and treating neoplastic cells, by introducing into the cell of interest an isolated polynucleotide sequence encoding a chimeric TNFα that is expressed on the surface of the cell. diabetic nestles boostWebSep 26, 1995 · A chimera oligonucleotide is provided that can be used in a process for obtaining transcripts and/or amplification of a target sequence of a nucleic acid, ... An oligonucleotide sequence is called "DNA type" if it is comprised of DNA or if it is a modified polynucleotide sequence that, in addition to the nucleic acid strand hybridization ... diabetic neuropathic pain clinical trialWebDec 4, 2024 · Chimeric nucleases enable genome editing in eukaryotic cell. Targeted genome editing with the hope of treating and curing diseases … cinebistro rewardsWebInhibition depended on the number and type of modified internucleotide linkages: a 20-mer phosphorothioate ODN had an IC50 of 21 nM, while a chimeric ODN with seven phosphorothioate linkages and an identical sequence showed no inhibition. diabetic neuropathies researchWebPolynucleotide definition, a sequence of nucleotides, as in DNA or RNA, bound into a chain. See more. diabetic neuropathy admaWebDec 3, 2004 · The term “mutated or chimeric gene” is used to indicate that mutated or chimeric polynucleotides are obtained at a high frequency by using the method … cinebistro short pumpWeb[0006] These studies are disclosed in, for example, Ribostem Limited in United Kingdom patent application serial number 0316089.2 filed on July 9, 2003 now abandoned, PCT applicat diabetic neuropathic ulcer medication